Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Intervention of AXL in EGFR Signaling via Phosphorylation and Stabilization of MIG6 in Non-Small Cell Lung Cancer.

International journal of molecular sciences - 4 Oct 2023

Yang Ya-Yu, Lin Sheng-Chieh, Lay Jong-Ding, Cho Chun-Yu, Jang Te-Hsuan, Ku Hsiu-Ying, Yao Chih-Jung, Chuang Shuang-En

Abstract excerpt

About 80% of lung cancer patients are diagnosed with non-small cell lung cancer (NSCLC). EGFR mutation and overexpression are common in NSCLC, thus making EGFR signaling a key target for therapy. While EGFR kinase inhibitors (EGFR-TKIs) are widely used and efficacious in treatment, increases in resistance and tumor recurrence with alternative survival pathway activation, such as that of AXL and MET, occur...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Non-Small-Cell Lung
Share to Chromatography, Liquid

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

Share to ErbB Receptors

Share to Neoplasm Recurrence, Local

Share to Phosphorylation

Share to Protein Kinase Inhibitors

Share to Tandem Mass Spectrometry

Source

Open in PubMed Open full text

Identifiers

PMID: 37834326
DOI: 10.3390/ijms241914879
PMCID: PMC10573631

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Intervention of AXL in EGFR Signaling via Phosphorylation and Stabilization of MIG6 in Non-Small Cell Lung Cancer.PMID 37834326Read ↗

Loss of MIG6 Accelerates Initiation and Progression of Mutant Epidermal Growth Factor Receptor-Driven Lung Adenocarcinoma.Semantic proximity Read ↗

Suppression of Mig-6 overcomes the acquired EGFR-TKI resistance of lung adenocarcinoma.Semantic proximity Read ↗

Phosphorylation of Mig6 negatively regulates the ubiquitination and degradation of EGFR mutants in lung adenocarcinoma cell lines.Semantic proximity Read ↗

Understanding the MIG6-EGFR Signaling Axis in Lung Tumorigenesis.Semantic proximity Read ↗

Suppression of Mig-6 overcomes the acquired EGFR-TKI resistance of lung adenocarcinomaSemantic proximity Read ↗

Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer.Semantic proximity Read ↗

AXL up-regulates PD-L1 inducing gefitinib resistance in EGFR mutated NSCLCSemantic proximity Read ↗

Role of the Receptor Tyrosine Kinase Axl and its Targeting in Cancer CellsSemantic proximity Read ↗

Axl-altered microRNAs regulate tumorigenicity and gefitinib resistance in lung cancerSemantic proximity Read ↗

M6A Methylation Regulators METTL3 and ALKBH5 are Risk Factors for EGFR-Mutant NSCLCSemantic proximity Read ↗

The miR‑625‑3p/AXL axis induces non‑T790M acquired resistance to EGFR‑TKI via activation of the TGF‑β/Smad pathway and EMT in EGFR‑mutant non‑small cell lung cancer.Semantic proximity Read ↗

Epidermal growth factor receptor mutation in combination with expression of MIG6 alters gefitinib sensitivity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.