Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RGS6 suppresses TGF-β-induced epithelial–mesenchymal transition in non-small cell lung cancers via a novel mechanism dependent on its interaction with SMAD4

28 Jul 2022

Abstract excerpt

Regulator of G-protein signaling 6 (RGS6) is a newly discovered tumor suppressor that has been shown to be protective in development of various cancers such as breast cancer and bladder cancer. But the mechanisms underlying these tumor-suppressing functions of RGS6 are not fully understood. Here, we discover a novel function of RGS6 in suppressing TGF-β-induced epithelial-mesenchymal transition (EMT) of non-small...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic factors in colorectal cancer
Share to Pancreatic and Hepatic Oncology Research
Share to TGF-β signaling in diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35902557
DOI: 10.1038/s41419-022-05093-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RGS6 suppresses TGF-β-induced epithelial–mesenchymal transition in non-small cell lung cancers via a novel mechanism dependent on its interaction with SMAD4PMID 35902557Read ↗

RGS6 inhibits the proliferation, migration, and invasion of breast cancer through the SMAD6-HMGA1 signaling pathwaySemantic proximity Read ↗

RGS3 acts as a tumor promoter by facilitating the regulation of the TGF-β signaling pathway and promoting EMT in ovarian cancerSemantic proximity Read ↗

SMAD6 Contributes to Patient Survival in Non–Small Cell Lung Cancer and Its Knockdown Reestablishes TGF-β Homeostasis in Lung Cancer CellsSemantic proximity Read ↗

MEGF6 Promotes the Epithelial-to-Mesenchymal Transition via the TGFβ/SMAD Signaling Pathway in Colorectal Cancer MetastasisSemantic proximity Read ↗

Distinct expression and prognostic value of members of SMAD family in non-small cell lung cancer.Semantic proximity Read ↗

SMAD4 mutation correlates with poor prognosis in non-small cell lung cancer.Semantic proximity Read ↗

GPR37 promotes the malignancy of lung adenocarcinoma via TGF-β/Smad pathwaySemantic proximity Read ↗

Unboxing the network among long non-coding RNAs and TGF-β signaling in cancerSemantic proximity Read ↗

NCAPG promotes the progression of lung adenocarcinoma via the TGF-β signaling pathwaySemantic proximity Read ↗

Long Noncoding RNA SNHG6 Functions as an Oncogene in Non-Small Cell Lung Cancer via Modulating ETS1 SignalingSemantic proximity Read ↗

Function and regulation of RGS family members in solid tumours: a comprehensive reviewSemantic proximity Read ↗

Deciphering the Role of ADAMTS6 in the Epithelial–Mesenchymal Transition of Lung Adenocarcinoma CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.