Article

The SMARCA4 R1157W mutation accelerates colorectal cancer progression by facilitating SMARCA4 recruitment to H4R3me2a and chromatin remodeling

2022-07-13

Abstract excerpt

<title>Abstract</title> <bold>Background:</bold> Genomic studies have demonstrated a high frequency of genetic alterations in components of the SWI/SNF complex including the core subunit SMARCA4. However, the mechanisms of tumorigenesis driven by SMARCA4 mutations, particularly in colorectal cancer (CRC), remain largely unknown. <bold>Methods:</bold> To reveal the role of the SMARCA4R1157W mutation...

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Literature Corpus work: 394d3c64-4c63-55cd-865b-c17861db731d
DOI: 10.21203/rs.3.rs-1816268/v1

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