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Article

Striatal specificity of gene expression dysregulation in Huntington's disease

18 Sept 2006

Abstract excerpt

Huntington's disease (HD) is a progressive neurodegenerative disorder caused by an expanded CAG repeat region in exon 1 of the HD gene. This mutation results in the presence of an abnormally long polyglutamine tract in the encoded protein, huntingtin (htt). A major question in this field is how the mutant htt protein, which is expressed ubiquitously throughout the brain and body, causes severe neuropathologic...

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PMID: 16983659
DOI: 10.1002/jnr.21046

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