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Article

sTREM2 Mediates the Correlation Between BIN1 Gene Polymorphism and Tau Pathology in Alzheimer's Disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2024

Guo Fan, Tan Meng-Shan, Hu Hao, Ou Ya-Nan, Zhang Ming-Zhan, Sheng Ze-Hu, Chi Hao-Chen, Tan Lan

Abstract excerpt

Background: Bridging integrator 1 (BIN1) gene polymorphism has been reported to play a role in the pathological processes of Alzheimer's disease (AD). Objective: To explore the association of BIN1 loci with neuroinflammation and AD pathology. Methods: Alzheimer's Disease Neuroimaging Initiative (ADNI, N = 495) was the discovery cohort, and Chinese Alzheimer's Biomarker and LifestylE (CABLE, N = 619) study was...

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PMID: 39240638
DOI: 10.3233/JAD-240372

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