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Article

Cross-platform Profiling of ctDNA Using ddPCR: Standardization of the Liquid Biopsy for Pediatric Diffuse Midline Glioma

2020-09-16

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold> Diffuse midline glioma (DMG) is a highly morbid pediatric brain tumor. Up to 80% of DMGs harbor mutations in histone H3-encoding genes, associated with poorer prognosis. We previously showed the feasibility of detecting H3 mutations in circulating tumor DNA (ctDNA) in the liquid biome of children diagnosed with DMG. However, detection of low ctDNA concentrations...

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Literature Corpus work
39450a7e-d306-582b-9f53-d0cca342f9f6
DOI
10.21203/rs.3.rs-75571/v1
Open publication

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Cross-platform Profiling of ctDNA&nbsp;Using ddPCR: Standardization of the Liquid Biopsy for Pediatric Diffuse Midline GliomaDOI 10.21203/rs.3.rs-75571/v1
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