Harmonization of postmortem donations for pediatric brain tumors and molecular characterization of diffuse midline gliomas.

doi:10.1038/s41598-020-67764-2

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Article

Harmonization of postmortem donations for pediatric brain tumors and molecular characterization of diffuse midline gliomas.

Scientific reports - 2 Jul 2020

Kambhampati Madhuri, Panditharatna Eshini, Yadavilli Sridevi, Saoud Karim, Lee Sulgi, Eze Augustine, Almira-Suarez M I, Hancock Lauren, Bonner Erin R, Gittens Jamila, Stampar Mojca, Gaonkar Krutika, Resnick Adam C, Kline Cassie, Ho Cheng-Ying, Waanders Angela J, Georgescu Maria-Magdalena, Rance Naomi E, Kim Yong, Johnson Courtney, Rood Brian R, Kilburn Lindsay B, Hwang Eugene I, Mueller Sabine, Packer Roger J, Bornhorst Miriam, Nazarian Javad

Abstract excerpt

Children diagnosed with brain tumors have the lowest overall survival of all pediatric cancers. Recent molecular studies have resulted in the discovery of recurrent driver mutations in many pediatric brain tumors. However, despite these molecular advances, the clinical outcomes of high grade tumors, including H3K27M diffuse midline glioma (H3K27M DMG), remain poor. To address the paucity of tissue for biological...

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PMID: 32616776
DOI: 10.1038/s41598-020-67764-2
PMCID: PMC7331588

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