Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Standardization of the liquid biopsy for pediatric diffuse midline glioma using ddPCR

3 Mar 2021

Abstract excerpt

Diffuse midline glioma (DMG) is a highly morbid pediatric brain tumor. Up to 80% of DMGs harbor mutations in histone H3-encoding genes, associated with poor prognosis. We previously showed the feasibility of detecting H3 mutations in circulating tumor DNA (ctDNA) in the liquid biome of children diagnosed with DMG. However, detection of low levels of ctDNA is highly dependent on platform sensitivity and sample...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Glioma Diagnosis and Treatment
Share to Sarcoma Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33658570
DOI: 10.1038/s41598-021-84513-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Standardization of the liquid biopsy for pediatric diffuse midline glioma using ddPCRPMID 33658570Read ↗

Cross-platform Profiling of ctDNA Using ddPCR: Standardization of the Liquid Biopsy for Pediatric Diffuse Midline GliomaSemantic proximity Read ↗

Droplet digital PCR-based detection of circulating tumor DNA from pediatric high grade and diffuse midline glioma patientsSemantic proximity Read ↗

Detection of Histone H3 mutations in cerebrospinal fluid-derived tumor DNA from children with diffuse midline glioma.Semantic proximity Read ↗

Liquid biopsy for pediatric diffuse midline glioma: a review of circulating tumor DNA and cerebrospinal fluid tumor DNASemantic proximity Read ↗

Liquid biopsy in H3K27M diffuse midline glioma.Semantic proximity Read ↗

Methodological Challenges of Digital PCR Detection of the Histone H3 K27M Somatic Variant in Cerebrospinal Fluid.Semantic proximity Read ↗

Single-molecule systems for detection and monitoring of plasma circulating nucleosomes and oncoproteins in Diffuse Midline GliomaSemantic proximity Read ↗

Serial H3K27M cell-free tumor DNA (cf-tDNA) tracking predicts ONC201 treatment response and progression in diffuse midline glioma.Semantic proximity Read ↗

Detection of H3F3A K27M or BRAF V600E in liquid biopsies of brain tumor patients as diagnostic and monitoring biomarker: impact of tumor localization and sampling method.Semantic proximity Read ↗

Efficient detection and monitoring of pediatric brain malignancies with liquid biopsy based on patient-specific somatic mutation screening.Semantic proximity Read ↗

Harmonization of postmortem donations for pediatric brain tumors and molecular characterization of diffuse midline gliomas.Semantic proximity Read ↗

The Use of Circulating Tumor DNA Assays and Liquid Biopsies in Pediatric Brain Tumors: A ReviewSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.