Article
Efficient detection and monitoring of pediatric brain malignancies with liquid biopsy based on patient-specific somatic mutation screening.
Neuro-oncology - 3 Aug 2023
Kojic Marija, Maybury Mellissa K, Waddell Nicola, Koufariotis Lambros T, Addala Venkateswar, Millar Amanda, Wood Scott, Pearson John V, Hansford Jordan R, Hassall Tim, Wainwright Brandon J
Abstract excerpt
BACKGROUND: Brain cancer is the leading cause of cancer-related death in children. Early detection and serial monitoring are essential for better therapeutic outcomes. Liquid biopsy has recently emerged as a promising approach for detecting these tumors by screening body fluids for the presence of circulating tumor DNA (ctDNA). Here we tested the limits of liquid biopsy using patient-specific somatic mutations to...
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