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Article

Detection of Histone H3 mutations in cerebrospinal fluid-derived tumor DNA from children with diffuse midline glioma.

Acta neuropathologica communications - 17 Apr 2017

Huang Tina Y, Piunti Andrea, Lulla Rishi R, Qi Jin, Horbinski Craig M, Tomita Tadanori, James C David, Shilatifard Ali, Saratsis Amanda M

Abstract excerpt

Diffuse midline gliomas (including diffuse intrinsic pontine glioma, DIPG) are highly morbid glial neoplasms of the thalamus or brainstem that typically arise in young children and are not surgically resectable. These tumors are characterized by a high rate of histone H3 mutation, resulting in replacement of lysine 27 with methionine (K27M) in genes encoding H3 variants H3.3 (H3F3A) and H3.1 (HIST1H3B). Detection...

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Identifiers

PMID: 28416018
DOI: 10.1186/s40478-017-0436-6
PMCID: PMC5392913

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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