Article

PAL-AI reveals genetic determinants that control poly(A)-tail length during oocyte maturation, with relevance to human fertility

2024-11-02

Abstract excerpt

In oocytes of mammals and other animals, gene regulation is mediated primarily through changes in poly(A)-tail length 1–9 . Here, we introduce PAL-AI, an integrated neural network machine-learning model that accurately predicts tail-length changes in maturing oocytes of frogs and mammals. We show that PAL-AI learned known and previously unknown sequence elements and their contextual features that control poly(A)-...

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Literature Corpus work: 393836c2-3e5a-5cca-9434-2bb2932a7f1e
DOI: 10.1101/2024.10.29.620940

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