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Somatic 9p24.1 alterations in HPV – head and neck squamous cancer dictate immune microenvironment and anti-PD-1 checkpoint inhibitor activity

17 Nov 2022

Abstract excerpt

Somatic copy number alterations (SCNAs), generally ( 1 ) losses containing interferons and interferon-pathway genes, many on chromosome 9p, predict immune-cold, immune checkpoint therapy (ICT)-resistant tumors ( 2 ); however, genomic regions mediating these effects are unclear and probably tissue specific. Previously, 9p21.3 loss was found to be an early genetic driver of human papillomavirus–negative (HPV – )...

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PMID: 36395141
DOI: 10.1073/pnas.2213835119

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