Article

POLQ-driven repair scars shape the immunogenic landscape of homologous recombination-deficient pancreatic cancer

2026-03-17

Abstract excerpt

<h4>ABSTRACT</h4> Pancreatic cancer (PC) is broadly resistant to immune checkpoint blockade, although a subset of homologous recombination-deficient (HRD) tumors exhibits durable immune engagement. The genomic features that distinguish these immune-responsive tumors from immune-inert HRD tumors remain poorly understood. Here we identify a microhomology-mediated end joining (MMEJ) repair scar, the MMEJ Deletion Fo...

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Literature Corpus work: cb66d8e9-b3c0-5118-b2f8-93ba744ab387
DOI: 10.64898/2026.03.15.711961

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