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Article

Basal activity of PINK1 and PRKN in cell models and rodent brain

2 Dec 2023

Abstract excerpt

The ubiquitin kinase-ligase pair PINK1-PRKN recognizes and transiently labels damaged mitochondria with ubiquitin phosphorylated at Ser65 (p-S65-Ub) to mediate their selective degradation (mitophagy). Complete loss of PINK1 or PRKN function unequivocally leads to early-onset Parkinson disease, but it is debated whether impairments in mitophagy contribute to disease later in life. While the pathway has been...

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PMID: 38041584
DOI: 10.1080/15548627.2023.2286414

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