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Morphological and bioenergetic demands underlying the mitophagy in post-mitotic neurons: the pink–parkin pathway

1 Jan 2014

Abstract excerpt

Evidence suggests a striking causal relationship between changes in quality control of neuronal mitochondria and numerous devastating human neurodegenerative diseases, including Parkinson's disease, Alzheimer's disease, Huntington's disease, and amyotrophic lateral sclerosis. Contrary to replicating mammalian cells with a metabolism essentially glycolytic, post-mitotic neurons are distinctive owing to (i) their...

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PMID: 24600391
DOI: 10.3389/fnagi.2014.00018

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