Back to search

Article

SAG1.3-derived Frizzled-targeting negative allosteric modulators

2024-02-20

Abstract excerpt

<title>Abstract</title> <p>Exaggerated Wingless/Int1 (WNT)/Frizzled (FZD) signaling contributes to pathologies including fibrosis and different forms of cancers. Thus, targeting FZDs as WNT receptors for therapeutic purposes constitutes a promising intervention if the imminent risk of unwanted side effects caused by the involvement of WNT/FZD signaling in stem cell regulation and tissue homeostasis can be control...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
39047478-a883-5038-89af-6edb6731491a
DOI
10.21203/rs.3.rs-3910794/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
SAG1.3-derived Frizzled-targeting negative allosteric modulatorsDOI 10.21203/rs.3.rs-3910794/v1
In silico docking yields small molecule compounds targeting the core of Frizzled 7 as negative allosteric modulatorsSemantic proximity
In silico docking yields small molecule compounds targeting the core of Frizzled 7 as negative allosteric modulatorsSemantic proximity
Synthetic Frizzled agonist and LRP antagonist for high-efficiency Wnt/β-catenin signaling manipulation in organoid cultures and <i>in vivo</i>Semantic proximity
A CRISPR screen reveals a WNT7B-FZD5 signaling circuit as a therapeutic opportunity in pancreatic cancerSemantic proximity
A Second WNT for Old Drugs: Drug Repositioning against WNT-Dependent CancersSemantic proximity
Frizzled Receptors in Tumors, Focusing on Signaling, Roles, Modulation Mechanisms, and Targeted Therapies.Semantic proximity
Targeting Wnt/β-Catenin Pathway for Drug TherapySemantic proximity
Targeting Wnts at the source--new mechanisms, new biomarkers, new drugs.Semantic proximity
New Target(s) for RNF43 Regulation: Implications for Therapeutic Strategies.Semantic proximity
A PDE3A-SLFN12 Molecular Glue Exhibits Significant Antitumor Activity in TKI-Resistant Gastrointestinal Stromal Tumors.Semantic proximity
Residue 6.43 defines receptor function in class F GPCRs.Semantic proximity
Hedgehog pathway inhibitors: a patent review (2009 – present)Semantic proximity
Select a neighboring publication to make it the new centre.