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Article

A PDE3A-SLFN12 Molecular Glue Exhibits Significant Antitumor Activity in TKI-Resistant Gastrointestinal Stromal Tumors.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Aug 2024

Takaki Emiri O, Kiyono Kunihiko, Obuchi Yutaka, Yamauchi Takeshi, Watanabe Takashi, Matsumoto Hideki, Karimine Miho, Kuniyoshi Yuki, Nishikori Shingo, Yokoyama Fumiharu, Nishimori Hikaru, Nabeshima Hiroshi, Nakamura Kazuhide

Abstract excerpt

PURPOSE: Gastrointestinal stromal tumor (GIST), the most common mesenchymal tumor with KIT or PDGFRA driver mutations, is typically treated with tyrosine kinase inhibitors (TKI). However, resistance to TKIs due to secondary mutations is a common challenge in advanced GISTs. In addition, there are currently no effective therapies for several other molecular subtypes, such as succinate dehydrogenase-deficient...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38864850
DOI: 10.1158/1078-0432.CCR-24-0096
PMCID: PMC11325149

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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