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Article

A Second WNT for Old Drugs: Drug Repositioning against WNT-Dependent Cancers

14 Jul 2016

Abstract excerpt

Aberrant WNT signaling underlies cancerous transformation and growth in many tissues, such as the colon, breast, liver, and others. Downregulation of the WNT pathway is a desired mode of development of targeted therapies against these cancers. Despite the urgent need, no WNT signaling-directed drugs currently exist, and only very few candidates have reached early phase clinical trials. Among different strategies...

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PMID: 27429001
DOI: 10.3390/cancers8070066

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