Article

In silico docking yields small molecule compounds targeting the core of Frizzled 7 as negative allosteric modulators

2025-07-17

Abstract excerpt

<title>Abstract</title> <p>Targeting the Frizzled family (FZD1-10) of WNT receptors pharmacologically has, despite substantial therapeutic potential, proven difficult. Given an almost complete lack of validated, effective small molecules targeting FZDs no putative ligand binding site has so far been identified. In order to target FZD7, a potential target for the treatment of intestinal tumors, we combined an appr...

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Literature Corpus work: 9a6e6f4e-b9cf-55be-b5a6-539b0d398e7b
DOI: 10.21203/rs.3.rs-6908411/v1

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