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Synthetic Frizzled agonist and LRP antagonist for high-efficiency Wnt/β-catenin signaling manipulation in organoid cultures and <i>in vivo</i>

2023-06-22

Abstract excerpt

Wnt/β-catenin signaling and its dysregulation play critical roles in the fate determination of stem cells and the pathology of various diseases. However, the application of translated Wnt ligand in regenerative medicine is hampered by its hydrophobicity and cross-reactivity with Frizzled (FZD) receptors. Here, we generate an engineered water-soluble, FZD subtype-specific agonist, RRP-pbFn, for high-efficiency Wnt/...

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Literature Corpus work
dc4c604a-99a8-5a9a-9664-43aa538f6e92
DOI
10.1101/2023.06.21.545860
Open publication

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Synthetic Frizzled agonist and LRP antagonist for high-efficiency Wnt/β-catenin signaling manipulation in organoid cultures and <i>in vivo</i>DOI 10.1101/2023.06.21.545860
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