Article

Targeting SerpinE1 reverses cellular features of Hutchinson-Gilford progeria syndrome

2021-11-05

Abstract excerpt

Hutchinson-Gilford progeria syndrome (HGPS) is a rare, fatal disease caused by Lamin A mutation, leading to altered nuclear architecture, loss of perinuclear heterochromatin and deregulated gene expression. HGPS patients eventually die by coronary artery disease and cardiovascular alterations. However, how deregulated transcriptional networks at the cellular level impact on the systemic disease phenotype is curren...

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Literature Corpus work: b49afcc9-6841-5f9d-bfb5-78c5d9653dd0
DOI: 10.1101/2021.11.05.467259

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