Article

Expansion <i>in situ</i> genome sequencing links nuclear abnormalities to hotspots of aberrant euchromatin repression

2024-09-26

Abstract excerpt

Microscopy and genomics are both used to characterize cell function, but approaches to connect the two types of information are lacking, particularly at subnuclear resolution. While emerging multiplexed imaging methods can simultaneously localize genomic regions and nuclear proteins, their ability to accurately measure DNA-protein interactions is constrained by the diffraction limit of optical microscopy. Here, we...

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Literature Corpus work: dae74a9d-d4e8-5c5d-958f-42cf53927b1e
DOI: 10.1101/2024.09.24.614614

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