Article

Proximity-dependent proteomics reveals extensive interactions of Protocadherin-19 with regulators of Rho GTPases and the microtubule cytoskeleton

2020-09-11

Abstract excerpt

Protocadherin-19 belongs to the cadherin family of cell surface receptors and has been shown to play essential roles in the development of the vertebrate nervous system. Mutations in human Protocadherin-19 ( PCDH19 ) lead to PCDH19 Female-limited epilepsy ( PCDH19 FLE) in humans, characterized by the early onset of epileptic seizures in children and a range of cognitive and behavioral problems in adults. Despit...

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Literature Corpus work: 831db0eb-876c-5102-a11c-5c265f38635e
DOI: 10.1101/2020.09.11.293589

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