Cardiac Overexpression of PDE4B Blunts β-Adrenergic Response and Maladaptive Remodeling in Heart Failure.

doi:10.1161/CIRCULATIONAHA.119.042573

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Article

Cardiac Overexpression of PDE4B Blunts β-Adrenergic Response and Maladaptive Remodeling in Heart Failure.

Circulation - 14 Jul 2020

Karam Sarah, Margaria Jean Piero, Bourcier Aurélia, Mika Delphine, Varin Audrey, Bedioune Ibrahim, Lindner Marta, Bouadjel Kaouter, Dessillons Matthieu, Gaudin Françoise, Lefebvre Florence, Mateo Philippe, Lechène Patrick, Gomez Susana, Domergue Valérie, Robert Pauline, Coquard Charlène, Algalarrondo Vincent, Samuel Jane-Lise, Michel Jean-Baptiste, Charpentier Flavien, Ghigo Alessandra, Hirsch Emilio, Fischmeister Rodolphe, Leroy Jérôme, Vandecasteele Grégoire

Abstract excerpt

BACKGROUND: The cyclic AMP (adenosine monophosphate; cAMP)-hydrolyzing protein PDE4B (phosphodiesterase 4B) is a key negative regulator of cardiac β-adrenergic receptor stimulation. PDE4B deficiency leads to abnormal Ca2+ handling and PDE4B is decreased in pressure overload hypertrophy, suggesting that increasing PDE4B in the heart is beneficial in heart failure. METHODS: We measured PDE4B expression in human...

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PMID: 32264695
DOI: 10.1161/CIRCULATIONAHA.119.042573

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