Article

Structures of PKA-phospholamban complexes reveal a mechanism of familial dilated cardiomyopathy

2021-11-16

Abstract excerpt

Several mutations identified in phospholamban (PLN) have been linked to familial dilated cardiomyopathy (DCM) and heart failure, yet the underlying molecular mechanism remains controversial. PLN interacts with sarco/endoplasmic reticulum Ca 2+ -ATPase (SERCA) and regulates calcium uptake, which is modulated by the protein kinase A (PKA)-dependent phosphorylation of PLN during the fight-or-flight response. Here, w...

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Literature Corpus work: 311ef64c-4185-5d3d-bd9b-2ef5ea9fbfa1
DOI: 10.1101/2021.11.16.468845

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