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Article

Arg92Leu-cTnT Alters the cTnC-cTnI Interface Disrupting PKA-Mediated Relaxation.

Circulation research - 25 Oct 2024

Lynn Melissa L, Jimenez Jesus, Castillo Romi L, Vasquez Catherine, Klass Mattie M, Baldo Anthony P, Kim Andrew, Gibson Cyonna, Murphy Anne M, Tardiff Jil C

Abstract excerpt

BACKGROUND: Impaired left ventricular relaxation, high filling pressures, and dysregulation of Ca2+ homeostasis are common findings contributing to diastolic dysfunction in hypertrophic cardiomyopathy (HCM). Studies have shown that impaired relaxation is an early observation in the sarcomere-gene-positive preclinical HCM cohort, which suggests the potential involvement of myofilament regulators in relaxation. A...

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Cardiomyopathy, Hypertrophic
Cyclic AMP-Dependent Protein Kinases
Mice
Molecular Dynamics Simulation
Mutation

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PMID: 39328062
DOI: 10.1161/CIRCRESAHA.124.325223
PMCID: PMC11502267

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