Article

ALKALs are <i>in vivo</i> ligands for ALK family Receptor Tyrosine Kinases in the neural crest and derived cells

2017-10-30

Abstract excerpt

Mutations in Anaplastic Lymphoma Kinase (ALK) are implicated in somatic and familial neuroblastoma, a paediatric tumour of neural crest-derived tissues. Recently, biochemical analyses have identified secreted small ALKAL proteins (FAM150, AUG) as potential ligands for human ALK and the related Leukocyte Tyrosine Kinase (LTK). In the zebrafish Danio rerio , DrLtk, which is similar to human ALK in sequence and doma...

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Literature Corpus work: 38eee206-dd98-54b0-9c3c-1bf275778c71
DOI: 10.1101/210096

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