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Article

Patient-associated mutations in Drosophila Alk perturb neuronal differentiation and promote survival.

Disease models & mechanisms - 1 Aug 2022

Pfeifer Kathrin, Wolfstetter Georg, Anthonydhason Vimala, Masudi Tafheem, Arefin Badrul, Bemark Mats, Mendoza-Garcia Patricia, Palmer Ruth H

Abstract excerpt

Activating anaplastic lymphoma kinase (ALK) receptor tyrosine kinase (RTK) mutations occur in pediatric neuroblastoma and are associated with poor prognosis. To study ALK-activating mutations in a genetically controllable system, we employed CRIPSR/Cas9, incorporating orthologs of the human oncogenic mutations ALKF1174L and ALKY1278S in the Drosophila Alk locus. AlkF1251L and AlkY1355S mutant Drosophila exhibited...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35972154
DOI: 10.1242/dmm.049591
PMCID: PMC9403751

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Patient-associated mutations in Drosophila Alk perturb neuronal differentiation and promote survival.PMID 35972154Read ↗

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