Article

Patient-associated mutations in <i>Drosophila</i> Alk perturb neuronal differentiation and promote survival

2022-03-30

Abstract excerpt

Activating Anaplastic Lymphoma Kinase (ALK) receptor tyrosine kinase (RTK) mutations occur in pediatric neuroblastoma and are associated with poor prognosis. To study ALK-activating mutations in a genetically controllable system we employed CRIPSR/Cas9, incorporating orthologues of the human oncogenic mutations ALK F1174L and ALK Y1278S in the Drosophila Alk locus. Alk F1251L and Alk Y1355S mutant Drosop...

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Literature Corpus work: 66b6071a-0e96-550b-894f-2d8a74f27c62
DOI: 10.1101/2022.03.30.486387

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