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Zebrafish blastomere screen identifies retinoic acid suppression of MYB in adenoid cystic carcinoma

12 Sept 2018

Abstract excerpt

Pluripotent cells have been used to probe developmental pathways that are involved in genetic diseases and oncogenic events. To find new therapies that would target MYB-driven tumors, we developed a pluripotent zebrafish blastomere culture system. We performed a chemical genetic screen and identified retinoic acid agonists as suppressors of c-myb expression. Retinoic acid treatment also decreased c-myb gene...

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PMID: 30209067
DOI: 10.1084/jem.20180939

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