Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Anaplastic lymphoma kinase: signalling in development and disease

27 May 2009

Abstract excerpt

RTKs (receptor tyrosine kinases) play important roles in cellular proliferation and differentiation. In addition, RTKs reveal oncogenic potential when their kinase activities are constitutively enhanced by point mutation, amplification or rearrangement of the corresponding genes. The ALK (anaplastic lymphoma kinase) RTK was originally identified as a member of the insulin receptor subfamily of RTKs that acquires...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Lung Cancer Research Studies
Share to Neuroblastoma Research and Treatments
Share to Neuroendocrine Tumor Research Advances

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19459784
DOI: 10.1042/bj20090387

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Anaplastic lymphoma kinase: signalling in development and diseasePMID 19459784Read ↗

Anaplastic lymphoma kinase in human cancer.Semantic proximity Read ↗

Anaplastic Lymphoma Kinase as a Therapeutic Target in Anaplastic Large Cell Lymphoma, Non-Small Cell Lung Cancer and NeuroblastomaSemantic proximity Read ↗

The emerging pathogenic and therapeutic importance of the anaplastic lymphoma kinase gene.Semantic proximity Read ↗

ALK gene alterations in cancer: biological aspects and therapeutic implications.Semantic proximity Read ↗

Development of anaplastic lymphoma kinase (ALK) small‐molecule inhibitors for cancer therapySemantic proximity Read ↗

ALK1 signaling in development and disease: new paradigmsSemantic proximity Read ↗

The role of anaplastic lymphoma kinase in pediatric cancers.Semantic proximity Read ↗

ALK in Neuroblastoma: Biological and Therapeutic ImplicationsSemantic proximity Read ↗

Anaplastic Lymphoma Kinase (ALK) Receptor Tyrosine Kinase: A Catalytic Receptor with Many FacesSemantic proximity Read ↗

Anaplastic lymphoma kinase: Role in cancer and therapy perspective.Semantic proximity Read ↗

Anaplastic Lymphoma Kinase as a Cancer Target in Pediatric Malignancies.Semantic proximity Read ↗

ALK receptor activation, ligands and therapeutic targeting in glioblastoma and in other cancersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.