Article

Evolutionary analyses guide selection of model systems to investigate proto-oncogene function in ALK and LTK

2019-10-07

Abstract excerpt

Model systems to investigate oncogene-driven cancer have played an essential role in the development of therapies for cancer. However, not all systems are appropriate for all therapeutic targets. Knowing where and when proto-oncogenes and their interactors originated in evolutionary history is key to understanding which organisms can serve as models. Here we investigate two tyrosine kinase receptors that underlie...

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Literature Corpus work: a7bbddb7-6875-5985-9b3d-e7b0cb78f6ba
DOI: 10.1101/795468

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