Article
Cell culture and Drosophila model systems define three classes of anaplastic lymphoma kinase mutations in neuroblastoma.
Disease models & mechanisms - 1 Mar 2013
Chand Damini, Yamazaki Yasuo, Ruuth Kristina, Schönherr Christina, Martinsson Tommy, Kogner Per, Attiyeh Edward F, Maris John, Morozova Olena, Marra Marco A, Ohira Miki, Nakagawara Akira, Sandström Per-Erik, Palmer Ruth H, Hallberg Bengt
Abstract excerpt
Neuroblastoma is a childhood extracranial solid tumour that is associated with a number of genetic changes. Included in these genetic alterations are mutations in the kinase domain of the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase (RTK), which have been found in both somatic and familial neuroblastoma. In order to treat patients accordingly requires characterisation of these mutations in terms of...
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