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Article

ALKALs are in vivo ligands for ALK family receptor tyrosine kinases in the neural crest and derived cells

9 Jan 2018

Abstract excerpt

Significance Neuroblastoma is a pediatric tumor arising from the neural crest. Dysregulation of the receptor tyrosine kinase ALK has been linked to neuroblastoma, making it important to understand its function in native conditions. In zebrafish, a related receptor—Ltk—is also expressed in neural crest and regulates development of specific pigment cells—iridophores. Ligands activating human ALK were recently...

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PMID: 29317532
DOI: 10.1073/pnas.1719137115

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