Article

A Multigenerational “Dirty” Mouse Model for Studying Trauma-Induced Immune Dysregulation and Infection Susceptibility

2025-06-24

Abstract excerpt

Trauma induces immune dysregulation in both humans and mice, increasing infection susceptibility. Mouse models are critical in research but have been criticized for lacking translational relevance. This study tested whether multigenerational “natural immune” (NI) mice – generated by co-housing C57BL/6 mice with “dirty” pet shop mice and breeding through multiple generations – would develop a more human-like immune...

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Literature Corpus work: 38e3ca73-e66e-5108-9621-f76f5223f39e
DOI: 10.1101/2025.06.18.660185

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