Article
Normalizing the environment recapitulates adult human immune traits in laboratory mice.
Nature - 28 Apr 2016
Beura Lalit K, Hamilton Sara E, Bi Kevin, Schenkel Jason M, Odumade Oludare A, Casey Kerry A, Thompson Emily A, Fraser Kathryn A, Rosato Pamela C, Filali-Mouhim Ali, Sekaly Rafick P, Jenkins Marc K, Vezys Vaiva, Haining W Nicholas, Jameson Stephen C, Masopust David
Abstract excerpt
Our current understanding of immunology was largely defined in laboratory mice, partly because they are inbred and genetically homogeneous, can be genetically manipulated, allow kinetic tissue analyses to be carried out from the onset of disease, and permit the use of tractable disease models. Comparably reductionist experiments are neither technically nor ethically possible in humans. However, there is growing...
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