Article
Mice with human immune system components as <i>in vivo</i> models for infections with human pathogens
8 Feb 2011
Abstract excerpt
Many pathogens relevant to human disease do not infect other animal species. Therefore, animal models that reconstitute or harbor human tissues are explored as hosts for these. In this review, we will summarize recent advances to utilize mice with human immune system components, reconstituted from hematopoietic progenitor cells in vivo. Such mice can be used to study human pathogens that replicate in leukocytes....
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