Article

Stress-driven emergence of heritable non-genetic drug resistance

2025-11-28

Abstract excerpt

<title>Abstract</title> <p>Drug resistance is the chief cause of treatment failure for therapies targeting chronic and infectious diseases. Whether the emergence of resistance is accelerated by environmental exposure to low levels of therapeutics remains controversial. Here, we report a non-genetic mechanism of stress adaptation that promotes heritable resistance to the widely used antifungal drug fluconazole. In...

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Literature Corpus work: 0d168ad6-240f-53ee-84f9-0b65ab5e809d
DOI: 10.21203/rs.3.rs-5744219/v1

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