Article

Stress-driven emergence of heritable non-genetic drug resistance

2024-12-21

Abstract excerpt

Drug resistance is the chief cause of treatment failure for therapies targeting chronic and infectious diseases. Whether the emergence of resistance is accelerated by environmental exposure to low levels of therapeutics remains controversial. Here, we report a non-genetic mechanism of stress adaptation that promotes heritable resistance to the widely used antifungal drug fluconazole. In the human fungal pathogen...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 784983ea-d984-5501-b59f-3101ed8143a9
DOI: 10.1101/2024.12.20.629823

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Stress-driven emergence of heritable non-genetic drug resistanceDOI 10.1101/2024.12.20.629823Read

Stress-driven emergence of heritable non-genetic drug resistanceSemantic proximity Read

Insight into the Mechanisms and Clinical Relevance of Antifungal HeteroresistanceSemantic proximity Read

Insight into the Mechanisms and Clinical Relevance of Antifungal HeteroresistanceSemantic proximity Read

Adaptation Under Pressure: Resistance and Stress Response Interplay in Clinical Aspergillus fumigatus IsolatesSemantic proximity Read

Polygenetic Determinants of Azole Resistance, Tolerance, and Heteroresistance in <i>Candida albicans</i>Semantic proximity Read

Antifungal tolerance and resistance emerge at distinct drug concentrations and rely upon different aneuploid chromosomesSemantic proximity Read

Distinct properties of human pathogenic Candida species revealed by systematic comparative phenotypic screening of clinical isolatesSemantic proximity Read

MAESTRO uncovers tandem paralog dynamics as a core driver of fungal stress adaptationSemantic proximity Read

Clearing the FoG: Antifungal tolerance is a subpopulation effect that is distinct from resistance and is associated with persistent candidemiaSemantic proximity Read

Cryptic Evolution of Heteroresistance as Adaptation to Treatment InterruptionsSemantic proximity Read

Antifungal Drug Concentration Impacts the Spectrum of Adaptive Mutations in Candida albicans.Semantic proximity Read

Chromatin Structure and Drug Resistance in Candida spp.Semantic proximity Read