Article

PNPLA3(148M) promotes hepatic steatosis by interfering with triglyceride hydrolysis through a gain-of-function mechanism

2024-08-04

Abstract excerpt

<h4>Background & Aims</h4> PNPLA3(148M) (patatin-like phospholipase domain-containing protein 3) is the most impactful genetic risk factor for steatotic liver disease (SLD), thus motivating a search for therapeutic modulators of its expression. A key unresolved issue is whether PNPLA3(148M) confers a loss- or gain-of-function. Here we used multiple approaches to further test the hypothesis that PNPLA3 causes stea...

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Literature Corpus work: b8afc67e-1b13-512a-a68b-48b7c4587419
DOI: 10.1101/2024.08.02.606015

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