Recombinant PNPLA3 protein shows triglyceride hydrolase activity and its I148M mutation results in loss of function.

doi:10.1016/j.bbalip.2013.12.006

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Article

Recombinant PNPLA3 protein shows triglyceride hydrolase activity and its I148M mutation results in loss of function.

Biochimica et biophysica acta - 4 Apr 2014

Pingitore Piero, Pirazzi Carlo, Mancina Rosellina M, Motta Benedetta M, Indiveri Cesare, Pujia Arturo, Montalcini Tiziana, Hedfalk Kristina, Romeo Stefano

Abstract excerpt

The patatin-like phospholipase domain containing 3 (PNPLA3, also called adiponutrin, ADPN) is a membrane-bound protein highly expressed in the liver. The genetic variant I148M (rs738409) was found to be associated with progression of chronic liver disease. We aimed to establish a protein purification protocol in a yeast system (Pichia pastoris) and to examine the human PNPLA3 enzymatic activity, substrate...

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Identifiers

PMID: 24369119
DOI: 10.1016/j.bbalip.2013.12.006

Genes

PNPLA3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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Recombinant PNPLA3 protein shows triglyceride hydrolase activity and its I148M mutation results in loss of function.PMID 24369119Read ↗

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PNPLA3 variant M148 causes resistance to starvation-mediated lipid droplet autophagy in human hepatocytes.Semantic proximity Read ↗

Hepatic patatin-like phospholipase domain-containing 3 levels are increased in I148M risk allele carriers and correlate with NAFLD in humans.Semantic proximity Read ↗

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The fatty liver disease-causing protein PNPLA3-I148M alters lipid droplet-Golgi dynamicsSemantic proximity Read ↗

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