Predicting cell-type-specific exon inclusion in the human brain reveals more complex splicing mechanisms in neurons than glia

Abstract excerpt

Alternative splicing contributes to molecular diversity across brain cell types. RNA-binding proteins (RBPs) regulate splicing, but the genome-wide mechanisms remain poorly understood. Here, we used RBP binding sites and/or the genomic sequence to predict exon inclusion in neurons and glia as measured by long-read single-cell data in human hippocampus and frontal cortex. We found that alternative splicing is harde...

Topics

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• Alternative Splicing
• Mental Disorders
• Molecular Sequence Annotation
• Neocortex
• Neurogenesis
• RNA-Binding Proteins
• RNA Splicing
• Single-Cell Analysis

Identifiers and source

Literature Corpus work

389637b9-550f-50b9-84ac-7522b937ddb3

DOI

10.1101/2024.03.18.585465