Article

T505A variant of ETV5 promotes proliferation of precursor B cells in a mouse model of acute lymphoblastic leukemia

2024-12-22

Abstract excerpt

Precursor B cell acute lymphoblastic leukemia (pre-B-ALL) arises as a result of precursor B cells acquiring driver mutations that lead to arrested differentiation and increased proliferation. Identification of driver mutations and understanding their biological function is critical to understanding pre-B-ALL development and advancing disease treatment. Using a mouse model of pre-B-ALL driven by deletion of genes e...

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Literature Corpus work: 3894cb30-5b5e-5ef5-9d61-975b5a731760
DOI: 10.1101/2024.12.19.629436

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