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Article

Structure of parkin reveals mechanisms for ubiquitin ligase activation.

Science (New York, N.Y.) - 21 Jun 2013

Trempe Jean-François, Sauvé Véronique, Grenier Karl, Seirafi Marjan, Tang Matthew Y, Ménade Marie, Al-Abdul-Wahid Sameer, Krett Jonathan, Wong Kathy, Kozlov Guennadi, Nagar Bhushan, Fon Edward A, Gehring Kalle

Abstract excerpt

Mutations in the PARK2 (parkin) gene are responsible for an autosomal recessive form of Parkinson's disease. The parkin protein is a RING-in-between-RING E3 ubiquitin ligase that exhibits low basal activity. We describe the crystal structure of full-length rat parkin. The structure shows parkin in an autoinhibited state and provides insight into how it is activated. RING0 occludes the ubiquitin acceptor site...

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Source

Identifiers

PMID: 23661642
DOI: 10.1126/science.1237908

Genes

RING1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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