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A Glycoprotein Mutation That Emerged during the 2013-2016 Ebola Virus Epidemic Alters Proteolysis and Accelerates Membrane Fusion.

mBio - 16 Feb 2021

Fels J Maximilian, Bortz Robert H, Alkutkar Tanwee, Mittler Eva, Jangra Rohit K, Spence Jennifer S, Chandran Kartik

Abstract excerpt

Genomic surveillance of viral isolates during the 2013-2016 Ebola virus epidemic in Western Africa, the largest and most devastating filovirus outbreak on record, revealed several novel mutations. The responsible strain, named Makona, carries an A-to-V substitution at position 82 (A82V) in the glycoprotein (GP), which is associated with enhanced infectivity in vitro Here, we investigated the mechanistic basis for...

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Share to Cathepsin L

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hemorrhagic Fever, Ebola

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Identifiers

PMID: 33593971
DOI: 10.1128/mBio.03616-20
PMCID: PMC8545129

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