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Article

Proteolytic processing of Middle East respiratory syndrome coronavirus spikes expands virus tropism.

Proceedings of the National Academy of Sciences of the United States of America - 25 Oct 2016

Park Jung-Eun, Li Kun, Barlan Arlene, Fehr Anthony R, Perlman Stanley, McCray Paul B, Gallagher Tom

Abstract excerpt

Middle East respiratory syndrome coronavirus (MERS-CoV) infects humans from zoonotic sources and causes severe pulmonary disease. Virions require spike (S) glycoproteins for binding to cell receptors and for catalyzing virus-cell membrane fusion. Fusion occurs only after S proteins are cleaved sequentially, first during their secretion through the exocytic organelles of virus-producing cells, and second after...

Topics

Coronavirus Infections
Gene Expression Regulation, Viral
Humans
Lung
Middle East Respiratory Syndrome Coronavirus
Mutation
Proteolysis
Spike Glycoprotein, Coronavirus
Viral Tropism
Virion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Virus Internalization

Source

Open in PubMed Open full text

Identifiers

PMID: 27791014
DOI: 10.1073/pnas.1608147113
PMCID: PMC5086990

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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