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Article

Proteolytic processing of Middle East respiratory syndrome coronavirus spikes expands virus tropism.

Proceedings of the National Academy of Sciences of the United States of America - 25 Oct 2016

Park Jung-Eun, Li Kun, Barlan Arlene, Fehr Anthony R, Perlman Stanley, McCray Paul B, Gallagher Tom

Abstract excerpt

Middle East respiratory syndrome coronavirus (MERS-CoV) infects humans from zoonotic sources and causes severe pulmonary disease. Virions require spike (S) glycoproteins for binding to cell receptors and for catalyzing virus-cell membrane fusion. Fusion occurs only after S proteins are cleaved sequentially, first during their secretion through the exocytic organelles of virus-producing cells, and second after...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27791014
DOI: 10.1073/pnas.1608147113
PMCID: PMC5086990

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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