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Article

Getting the message across, STAT! Design principles of a molecular signaling circuit.

The Journal of cell biology - 25 Oct 2004

Vinkemeier Uwe

Abstract excerpt

The STAT transcription factors, usually referred to as "latent cytoplasmic proteins," have experienced a fundamental reevaluation of their dynamic properties. This review focuses on recent studies that have identified continuous transport factor-independent nucleocytoplasmic cycling of STAT1, STAT3, and STAT5 as a basic principle of cytokine signaling. In addition, molecular mechanisms that modulate flux rates or...

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Topics

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Share to Active Transport, Cell Nucleus
Share to Cytokines
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to STAT1 Transcription Factor

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Source

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Identifiers

PMID: 15504906
DOI: 10.1083/jcb.200407163
PMCID: PMC2172545

Genes

STAT1
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Getting the message across, STAT! Design principles of a molecular signaling circuit.PMID 15504906Read ↗

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STATs: An Old Story, Yet Mesmerizing.Semantic proximity Read ↗

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Stat3 isoforms, alpha and beta, demonstrate distinct intracellular dynamics with prolonged nuclear retention of Stat3beta mapping to its unique C-terminal end.Semantic proximity Read ↗

Stat5B shuttles between cytoplasm and nucleus in a cytokine-dependent and -independent manner.Semantic proximity Read ↗

Dynamic Trafficking of STAT5 Depends on an Unconventional Nuclear Localization SignalSemantic proximity Read ↗

Unexpected functional role of the transactivation domain for nuclear import of STAT5Semantic proximity Read ↗

SO MANY LIGANDS, SO FEW TRANSCRIPTION FACTORS: A NEW PARADIGM FOR SIGNALING THROUGH THE STAT TRANSCRIPTION FACTORSSemantic proximity Read ↗

A New Perspective: Mitochondrial Stat3 as a Regulator for Lymphocyte FunctionSemantic proximity Read ↗

STAT2 Is a Pervasive Cytokine Regulator due to Its Inhibition of STAT1 in Multiple Signaling PathwaysSemantic proximity Read ↗

STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-α3Semantic proximity Read ↗

Real time analysis of STAT3 nucleocytoplasmic shuttling.Semantic proximity Read ↗

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