Article
STAT5B leukemic mutations, altering SH2 tyrosine 665, have opposing impacts on immune gene programs.
Life science alliance - 1 Jul 2025
Lee Hye Kyung, Chen Jichun, Philips Rachael L, Lee Sung-Gwon, Feng Xingmin, Wu Zhijie, Liu Chengyu, Schultz Aaron B, Dalzell Molly, Meggendorfer Manja, Haferlach Claudia, Birnbaum Foster, Sexton Joel A, Keating Amy E, O'Shea John J, Young Neal S, Villarino Alejandro V, Furth Priscilla A, Hennighausen Lothar
Abstract excerpt
STAT5B is a vital transcription factor for lymphocytes. Here, the function of two STAT5B mutations from human T-cell leukemias: one substituting tyrosine 665 with phenylalanine (STAT5BY665F) and the other with histidine (STAT5BY665H), was interrogated. In silico modeling predicted divergent energetic effects on homodimerization with a range of pathogenicity. In primary T cells in vitro, STAT5BY665F showed...
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