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Article

Deletion of the carboxyl-terminal transactivation domain of MGF-Stat5 results in sustained DNA binding and a dominant negative phenotype.

Molecular and cellular biology - 1 Oct 1996

Moriggl R, Gouilleux-Gruart V, Jähne R, Berchtold S, Gartmann C, Liu X, Hennighausen L, Sotiropoulos A, Groner B, Gouilleux F

Abstract excerpt

The Stat (signal transducer and activator of transcription) factors transmit cytokine, growth factor, and hormone responses. Seven members of the Stat gene family are known. MGF-Stat5a has been discovered as a mediator of the prolactin response in mammary epithelial cells. Two closely related variants of Stat5, Stat5a and Stat5b, are encoded by distinct genes. We examined the functional properties of the carboxyl...

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Identifiers

PMID: 8816482
DOI: 10.1128/MCB.16.10.5691
PMCID: PMC231569

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Deletion of the carboxyl-terminal transactivation domain of MGF-Stat5 results in sustained DNA binding and a dominant negative phenotype.PMID 8816482Read ↗

Expression of a carboxy terminally truncated Stat5 with no transactivation domain in the mammary glands of transgenic mice inhibits cell proliferation during pregnancy, delays onset of milk secretion, and induces apoptosis upon involution.Semantic proximity Read ↗

Naturally occurring dominant negative variants of Stat5.Semantic proximity Read ↗

STAT5b: A master regulator of key biological pathwaysSemantic proximity Read ↗

The coactivator of transcription CREB-binding protein interacts preferentially with the glycosylated form of Stat5.Semantic proximity Read ↗

Disease-Associated Mutations of the STAT5B SH2 Domain Regulate Cytokine-Driven Enhancer Function and Mammary Development.Semantic proximity Read ↗

STAT5B SH2 variants disrupt mammary enhancers and the stability of genetic programs during pregnancySemantic proximity Read ↗

Selective coupling of STAT factors to the mouse prolactin receptor.Semantic proximity Read ↗

Overexpression and forced activation of stat5 in mammary gland of transgenic mice promotes cellular proliferation, enhances differentiation, and delays postlactational apoptosis.Semantic proximity Read ↗

Amino-terminal signal transducer and activator of transcription (STAT) domains regulate nuclear translocation and STAT deactivation.Semantic proximity Read ↗

STAT5b deficiency: lessons from STAT5b gene mutations.Semantic proximity Read ↗

Genomic Mutations of the STAT5 Transcription Factor Are Associated with Human Cancer and Immune Diseases.Semantic proximity Read ↗

Unexpected functional role of the transactivation domain for nuclear import of STAT5Semantic proximity Read ↗

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