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Article

STAT proteins: a kaleidoscope of canonical and non-canonical functions in immunity and cancer

22 Nov 2021

Abstract excerpt

STAT proteins represent an important family of evolutionarily conserved transcription factors that play key roles in diverse biological processes, notably including blood and immune cell development and function. Classically, STAT proteins have been viewed as inducible activators of transcription that mediate cellular responses to extracellular signals, particularly cytokines. In this 'canonical' paradigm, latent...

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PMID: 34809691
DOI: 10.1186/s13045-021-01214-y

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